William Hopkins was born in Greenville, South Carolina. At the age of nine months, he was adopted by a couple who were unable to conceive. Growing up, he was called "Billy."

Hopkins became interested in pursuing an acting career, although his wife disapproved of it and she soon left him, taking their daughter with her.

Hopkins appeared in more than 100 film and television roles in a career of more than 40 years, including the major studio films The Wild Bunch 

Hopkins was married to Sian Eleanor Green from 1989 until his death; they had a son in 1995. After six years of professional inactivity, Hopkins returned to acting, reading scripts, 

Hopkins died on May 28, 2022, after suffering a heart attack nineteen days before. He was 80 years old.

As per data pooled from multiple publications, Bo Hopkins net worth was estimated $3 million. However, a few publication peg his net worth as $66 million which appears to be incorrect.

He was Recognize an individual who has a significant on the global optics and photonics community or society hereby winning Golden Boot Award in 1995

Hopkins starred or co-starred in a number of made-for-television movies of the mid-1970s, including Gondola (1973), Judgment: The Court Martial of Lieutenant William Calley (1975).

Hopkins appeared in more than 100 film and television roles in a career of more than 40 years, including the major studio films The Wild Bunch (1969), The Bridge at Remagen (1969),

He appeared in two films that were nominated for the Best Picture Oscar: American Graffiti (1973) and Midnight Express (1978).